Short-course intensification with enfuvirtide in virologic failure: impact on intracellular HIV reservoir and on viral tropism (INNOVE study)
نویسندگان
چکیده
Background Overall, studies of ART intensification in suppressed patients showed no reduction in HIV reservoir, as assessed by proviral DNA. Limited data about impact of ART intensification are available for failing patients harbouring multidrug resistant viruses. We studied the effects of intensification with enfuvirtide (ENF) on intracellular HIV reservoir and tropism evolution under treatment selective pressure in this clinical setting.
منابع مشابه
Role and evolution of viral tropism in patients with advanced HIV disease receiving intensified initial regimen in the ANRS 130 APOLLO trial.
OBJECTIVES The aims of the study were to assess in patients with advanced HIV disease receiving antiretroviral therapy (ART) intensification with enfuvirtide (i) resistance at virological failure (VF), (ii) impact of baseline tropism on immunovirological response, and (iii) HIV-1 DNA tropism evolution during ART. METHODS The ANRS 130 APOLLO randomized trial evaluated in naive patients the imm...
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